Description
Amoxycillin is a semi-synthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against many gram-positive and gram-negative microorganisms. Amoxycillin is bactericidal against susceptible organisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell wall mucopeptides. Dynamox competitively inhibit penicillin binding proteins, leading to upregulation of autolytic enzymes and inhibition of cell wall synthesis. Dynamox has a long duration of action as it is usually given twice daily. Dynamox has a wide therapeutic range as mild overdoses are not associated with significant toxicity. Patients should be counselled regarding the risk of anaphylaxis, Clostridium difficile infections, and bacterial resistance.
Indications
Dynamox is used for the treatment of the following bacterial infections when caused by susceptible organisms: Respiratory tract, ENT infections : Acute and chronic bronchitis, pneumonia, otitis media, sinusitis, tonsillitis, pharyngitis & laryngitis, lobar & bronchopneumonia, chronic bronchial sepsis. Urinary tract infections : Pyelonephritis, cystitis and urethritis. Obstetric & gynaecological infections : Bacteriuria in pregnancy, septic abortion, intra-abdominal sepsis and puerperal sepsis. Gastro-intestinal infections : Typhoid and paratyphoid. Skin & soft tissue infections : Cellulitis, infected wounds and abscesses. Generalized infections : Septicemia, bacterial endocarditis, meningitis, peritonitis and osteomyelitis. Venereal infections : Gonorrhea and syphilis. Dynamox may also be used as prophylactic cover for patients at risk of developing endocarditis when undergoing dental surgery.
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